Olivier REYNARD
Ebola virus infection : toward a better understanding of the initial steps
Summary of the presentation :
: Faintly studied for nearly fifty years, filoviruses including Ebola virus have dominated the media with the emergence of unprecedented epidemics in West Africa in early 2014 and currently in DRC. The Ebola virus is responsible for fatal hemorrhagic fever in humans and monkeys. This virus is classified as biosafety level 4, the highest one in the classification of pathogens. It belongs to the mononegavirales which groups the non-segmented negative single stranded RNA viruses. Ebola is transmitted through direct contact with infected bodily fluids while not by aerosol exposure. During our research projects we have developed tools and ex vivo models to mimic the primary infection cycle or to study the viral pathogenesis in different target organs. Our results have allowed us to better understand the viral infection cycle and some aspects of the pathogenesis.
Professional background : PhD in molecular virology I’ve worked in fundamental and applied virology notably on Ebola and Crimean Congo Haemoragic fever viruses in BSL4 lab since 2004. Apart from my work at inserm I’m also external associate professor at UCly were I teach biosafety as well as virology for Master 1.